November 11, 2013

HCV Update: Simeprevir and Sofosbuvir

...Researchers found that a new pill that combines two drugs, sofosbuvir and ledipasvir, which would be taken over a much shorter time frame (12 weeks), was successful in essentially eliminating the strain of hepatitis C that is currently untreatable. "Our data lend support to the possibility of effectively treating all patients with genotype-1 HCV with a brief, all-oral, once-daily regimen that has no known safety issues," the study says. http://www.usnews.com/news/articles/2013/11/05/new-pill-may-help-those-with-untreatable-hepatitis-c == Unlike previous HCV treatments, which sought to enhance the immune system with interferon and other drugs, the latest group of oral medications interferes with the virus’s ability to replicate and make proteins. A US Food and Drug Administration (FDA) board recommended two such drugs—simeprevir, made by Johnson & Johnson in New Brunswick, New Jersey, and sofosbuvir from Gilead Sciences in Foster City, California—for approval last week. When each is taken in combination with a drug called ribavirin, the treatment eliminates hepatitis C in around 80 percent of people. “This is the first time in the history of humankind that we have a cure for a viral disease,” says pharmacologist Raymond Schinazi of Emory University in Atlanta, Georgia. http://www.scientificamerican.com/article.cfm?id=us-to-approve-potent-oral-drugs-for-hepatitis-c === Among the new drugs, the one garnering the most excitement is sofosbuvir, from Gilead Sciences, which is expected to be approved by the Food and Drug Administration by Dec. 8. It inhibits the virus’s polymerase enzyme, which builds new genomes out of RNA so the virus can replicate. Sofosbuvir is an evil decoy of sorts. It looks like a building block of RNA. But once it is mistakenly incorporated into the RNA chain, the chain cannot grow and the virus cannot reproduce. The effectiveness of the new drugs can vary depending on which strain of hepatitis C, known as genotypes, the patient has. People infected with hepatitis C genotypes 2 and 3 — which account for 20 to 25 percent of cases in the United States — will take sofosbuvir with ribavirin but without interferon, making this the first all-oral treatment for hepatitis C. Treatment for genotype 2 will be 12 weeks, but for genotype 3 it will probably be 24 weeks. Genotype 1, which accounts for more than 70 percent of patients in the United States, will still require interferon and ribavirin along with sofosbuvir, but only for 12 weeks. In a clinical trial, about 90 percent of previously untreated patients taking this combination achieved a sustained virologic response. The combination is expected to be somewhat less effective in those for whom previous treatments did not work. http://www.nytimes.com/2013/11/05/health/hepatitis-c-a-silent-killer-meets-its-match.html

7 comments:

Roger Wax Jr said...
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Ryan35 said...
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Ryan35 said...

To cure chronic hepatitis problem take Sofovir antiviral oral tablet.

Roger M said...

I'm not sure if this is on point but isn't sofosbuvir by itself enough to cure Hepatitis C? According to Fix Hep C buyers club, some genotypes don't need simeprevir and 400mg pills of sofosbuvir are enough to achieve a 95% cure rate.

Herry jonson said...

Buy sofosbuvir medication at an affordable price. Delivery from the manufacturer in India with very good and best quality and services.

JOHNSON KATE said...

As a sign of gratitude for how my husband was saved from hepatitis b, i decided to reach out to those still suffering from this.
My husband was diagnosed of hepatitis b in 2013 and it was really tough and heartbreaking for me because he was my all and the symptoms were terrible, he always have Joint pain , and he always complain of Weakness of the body . we tried various therapies prescribed by our neurologist but none could cure him. I searched for a cure and i saw a testimony by someone who was cured and so many other with similar body problem, and he left the contact of the doctor who had the cure to hepatitis b. I never imagined hepatitis b has a natura cure not until i contacted him and he assured me my husband will be fine. I got the herbal medication he recommended and my husband used it and in one months he was fully okay even up till this moment he is so full of life. hepatitis b has a cure and it is a herbal cure contact the doctor for more info on drwilliams098765@gmail.com on how to get the medication. Thanks for reading my story

Alifseye.com said...

This prevailing disease has become the plague for the whole world. As the time goes by the victims of hepatitis are increasing rapidly and my mother is one of them who has hepatitis c. Thank you for sharing the post and i am looking forward to more from you.